Product Name: Isopropyl Acetate
Chemical Formula: C5H10O2
Molecular Weight: 102.13 g/mol
CAS Number: 108-21-4
Synonyms: 2-Propyl Acetate, Propan-2-yl Acetate, Isopropyl Ethanoate
Recommended Use: Solvent in coatings, inks, adhesives, and chemical syntheses
Supplier Details: Manufacturer or distributor contact information should appear on product label
Emergency Contact: Local poison control center or national emergency hotline
GHS Classification: Flammable liquid Category 2, Eye irritation Category 2A, Specific target organ toxicity (single exposure) Category 3
Pictograms: Flame, Exclamation mark
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor. Causes serious eye irritation. May cause drowsiness or dizziness.
Precautionary Statements: Keep away from open flames and hot surfaces. Avoid breathing vapors. Use protective equipment as advised. In case of fire, use dry chemical, CO2, or foam extinguishers.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Target Organs: Eyes, central nervous system
Isopropyl Acetate: 99–100%
Impurities: Trace amounts of water, isopropanol, and acetic acid possible depending on production
Other Additives: Not typically present
EC Number: 203-561-1
REACH Registration Number: See product supplier for details
Inhalation: Move person to fresh air, support breathing if needed, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and soap, medical care if irritation continues
Eye Contact: Flush eyes thoroughly with water for at least 15 minutes, remove contact lenses, seek immediate medical help if discomfort or visual changes remain
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical advice
Most Important Symptoms: Eye irritation, headache, drowsiness, nausea, respiratory discomfort
Advice to Physician: Treat symptomatically, monitor for respiratory depression
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical powder
Unsuitable Media: Water jet can spread fire
Specific Hazards: Vapors may travel and ignite at distant sources, combustion produces carbon monoxide and carbon dioxide
Protective Equipment: Full protective clothing including self-contained breathing apparatus recommended for fire-fighters
Special Precautions: Cool containers exposed to fire with water spray to prevent rupture and explosion, avoid inhaling combustion byproducts
Personal Precautions: Evacuate area, ventilate, eliminate all sources of ignition, use protective gear including gloves and organic vapor respirator
Environmental Precautions: Prevent entry into sewers, groundwater, or waterways; notify authorities if environmental contamination occurs
Spill Containment: Dike or absorb with inert material like vermiculite or sand, collect into labeled containers for disposal
Cleanup Methods: Use non-sparking tools, avoid contact and inhalation, wash area with plenty of water after cleanup
Handling: Use in well-ventilated areas, ground and bond containers when transferring, avoid sparks and static discharge, avoid contact with skin, eyes, and clothing
Storage Conditions: Store in tightly closed containers in cool, dry, well-ventilated spaces, away from heat and ignition sources
Storage Incompatibilities: Strong acids, alkalies, oxidizers
Packing Materials: Use approved containers designed for flammable liquids
Advice for Safe Handling: Practice good industrial hygiene, wash thoroughly after use, keep containers upright and tightly sealed
Occupational Exposure Limits: OSHA PEL: 250 ppm (TWA), ACGIH TLV: 250 ppm (TWA)
Engineering Controls: General and local exhaust ventilation required for vapor control
Personal Protective Equipment:
- Respiratory: NIOSH-approved organic vapor respirator when ventilation is inadequate
- Skin: Chemical-resistant gloves (nitrile or neoprene recommended)
- Eyes: Safety goggles or full-face shield
Hygiene Measures: Avoid eating, drinking, smoking during handling, wash hands before breaks and at end of tasks
Appearance: Clear, colorless liquid
Odor: Fruity, pleasant, slightly ester-like
Odor Threshold: Approximately 1.2 ppm
pH: Not measurable (neutral in water)
Melting Point: -73°C
Boiling Point: 89°C
Flash Point: 12–16°C (closed cup)
Evaporation Rate: 1.8 (n-butyl acetate = 1)
Flammability: Highly flammable liquid and vapor
Explosive Limits: 1.0% (lower) – 7.1% (upper) by volume in air
Vapor Pressure: 32 mmHg at 20°C
Vapor Density: 3.5 (air=1)
Relative Density: 0.87 @ 20°C
Solubility: 3.3 g/100 ml in water at 25°C, miscible with many organic solvents
Partition Coefficient (log Kow): 1.3
Auto-ignition Temperature: 460°C
Decomposition Temperature: Not established
Viscosity: 0.62 mPa.s @ 20°C
Chemical Stability: Stable under normal temperatures and pressures; vapor can form explosive mixtures with air
Possible Reactions: Violent reaction with strong oxidizing agents; may hydrolyze in alkaline or acidic conditions producing isopropanol and acetic acid
Hazardous Decomposition: Carbon monoxide, carbon dioxide, potentially toxic fumes
Polymerization: Not known to occur
Incompatible Materials: Strong acids, alkalis, oxidizers such as hydrogen peroxide or nitric acid
Acute Toxicity: Oral LD50 (rat): ~6750 mg/kg; Dermal LD50 (rabbit): ~13,000 mg/kg; Inhalation LC50 (rat, 4h): ~16,000 ppm
Skin Corrosion/Irritation: Mild to moderate skin irritation possible
Eye Damage/Irritation: Causes irritation, tearing, and redness
Respiratory Effects: Vapors may cause drowsiness, dizziness, headaches, and respiratory tract irritation
Chronic Effects: No long-term human health data available; animal studies do not indicate severe chronic effects
Sensitization: No evidence of sensitization in animal studies
Mutagenicity/Carcinogenicity: Not classified as carcinogenic or mutagenic by OSHA, IARC, or NTP
Ecotoxicity: Toxic to aquatic organisms at high concentrations; fish LC50 (96 hr): ~100 mg/L (Pimephales promelas); Daphnia EC50 (48 hr): ~245 mg/L
Persistence and Degradation: Readily biodegradable in standard OECD tests
Bioaccumulation: Low potential (log Kow: 1.3)
Mobility in Soil: High solvent mobility, may leach in soil under certain conditions
Other Adverse Effects: Volatile organic compound contributing to air pollution; precaution suggested to minimize releases
Waste Treatment: Burn in approved hazardous waste incineration facility, recover solvent where feasible
Contaminated Packaging: Empty container poses fire risk, must be properly disposed of or recycled according to local laws
Relevant Regulations: Dispose in accordance with national and local regulations, do not dump into environment
Preferred Disposal Methods: High-temperature incineration to destroy residual solvent
UN Number: UN1220
Proper Shipping Name: Isopropyl Acetate
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: II
Labels Required: Flammable liquid
Special Precautions: Keep containers upright and secure, segregate from oxidizers or incompatible chemicals during shipping
ADR/RID, IMDG, IATA: Transported under relevant international guidelines for flammable liquids
Environmental Hazards (IMDG): Not marine pollutant by current criteria
TSCA: Listed
EINECS: 203-561-1
REACH: Registered substance; further information available via Safety Data Sheet from supplier
SARA Title III: Not subject to reporting; check state and federal laws for updates
OSHA: Regulated as hazardous flammable liquid
WHMIS Classification (Canada): B2 – Flammable liquid, D2B – Toxic material causing other toxic effects
Other Regulations: Users should check regional product safety, environmental, and workplace hazard regulations before use
